14.2
Choosing regimen and time of starting in special situations
Clinical HIV Guidelines, 5th Edition, 2022. Chapter 14, Understanding ART regimens and formulations.
Clinical description
Table 18: Choosing ART regimen and timing of initiation in special situations Condition Timing for ART initiation 3-19.9kg 20-24.9kg 25-29.9kg 30kg+ Anaemia • As soon as possible 15PP 15PA 15A 13A (<8g/dl)
Active TB • Pulmonary and extra- See section 17 on page 82 pulmonary TB (except meningitis): within 14 days of diagnosis.
- TBT + ART can be started on
the same day if the patient is stable. Don’t delay TBT or ART
- Delay ART initiation by 5 weeks
after starting treatment for TB meningitis to reduce IRIS risk.
Cryptococcal • Delay ART initiation by 5 weeks 15PP 15PA 15A 13A meningitis after starting treatment for acute CM to reduce IRIS risk.
Jaundice • Refer to District / Central 15PP 15PA 15A 13A Hospital for lab monitoring
- After investigation and
stabilisation Renal failure • Refer to District / Central 15PP 15PA 15A 15A Hospital for lab monitoring
- Start within 7 days of diagnosis
Psychiatric • As soon as possible 9PP 9PA 9PA 7A history • Reliable guardian needed Epilepsy • As soon as possible 4PP 4PP 4PA 5A
- Reliable guardian needed
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