14.1.5
Contraindications
Clinical HIV Guidelines, 5th Edition, 2022. Chapter 14, Understanding ART regimens and formulations.
Clinical description
- Most contraindications are not absolute for a specific regimen: balance risks, benefits and
alternatives. A suitable alternative regimen can be chosen from Table 16. The following conditions are absolute contraindications:
o Patients who developed severe toxicity to any specific ARV (hepatitis or Stevens - Johnson syndrome from NVP or EFV, severe anaemia from AZT, ABC hypersensitivity) must NEVER AGAIN be given a regimen containing the responsible ARV.
o Do not use TDF-containing regimens in severe renal failure (creatinine clearance <50ml/min).
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