14.1
Classification of individual ARVs
Clinical HIV Guidelines, 5th Edition, 2022. Chapter 14, Understanding ART regimens and formulations.
Clinical description
- Main classification is based on mode of action against HIV replication.
- Sub-classification is based on biochemical structure of the drug.
- Only ARVs with the same dosing interval are available as fixed-dose combinations.
Table 14: Classification of ARVs Mode of action Biochem. structure Abbrev. ARVs Dosing interval AZT 12-hourly 12- or 24- Nucleosides NRTI 3TC, ABC hourly Reverse Transcriptase Entecavir (ETV)* 24-hourly Inhibitors Nucleotide NtRTI TDF 24-hourly NVP 12-hourly Non-Nucleosides NNRTI EFV 24-hourly ATV/r 24-hourly Protease Inhibitors PI DRV 12-hourly LPV/r 12-hourly Integrase Strand INSTI DTG 24-hourly Transfer Inhibitor *ETV is used for treating chronic HepB (not HIV). Needed for HIV/HepB co-infected patients who cannot take TDF/3TC containing ART (e.g. children under 30kg, patients with renal insufficiency)
Check doses against the printed guideline and your clinical judgement before treating a patient. Spotted an error? Report it from the contact links below.
Need this without data?
The app holds every guideline on your device, with calculators, bookmarks and notes.