5.4.1
Indications for Fresh Frozenplasma
Malawi Standard Treatment Guidelines, 6th Edition, 2023. Chapter 5, Blood and Haematology.
Clinical Description
- Replacement of single factor deficiencies (if single factor concentrates are not available)
- Immediate reversal of warfarin effect
- Vitamin K deficiency associated with active bleeding
- Acute disseminated intravascular coagulopathy (DIC)
- Thrombotic thrombocytopenic purpura (TTP)
- May be used in massive transfusion or liver disease
Dose:
- 15-20ml/kg
Side effects:
- Acute allergic reactions are common.
- Febrile, non haemolytic reaction
- Viral transmission
- Bacterial contamination – sepsis
No justification for use in hypovolemia, nutritional support in protein losing states or/and plasma exchange except in TTP. FFP transfusion does not require group and crossmatching.
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