17.1.10
Neurosyphilis
Malawi Standard Treatment Guidelines, 6th Edition, 2023. Chapter 17, Sexually Transmitted Infections.
Pharmacological
- Higher penicillin doses are necessary to ensure that levels in the CSF do not fall below required amount throughout the course of treatment
Treatme nt
Adults
- Give Benzylpenicillin 4MU IV 6 hourly for 14 days then
- Give Benzathine Penicillin 2.4 MU IM once weekly for 3 consecutive weeks
Alternatively, if confirmed hypersensitivity to penicillin:
- Doxycycline 200mg every 12 hours for 30 days Note: In pregnancy: substitute Doxycycline with Erythromycin 500mg 6 hourly for 30 days
Check doses against the printed guideline and your clinical judgement before treating a patient. Spotted an error? Report it from the contact links below.
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