1.4.1
Second-line Treatment — Artesunate-Amodiaquine (ASAQ)
Guidelines for the Treatment of Malaria in Malawi, 6th Edition, 2025. Chapter 2, Uncomplicated Malaria.
Treatment
The recommended second-line treatment for uncomplicated malaria in Malawi is artesunate-amodiaquine (ASAQ). It is available in fixed-dose combinations with tablets containing 25 mg/67.5 mg, 50 mg/135 mg and 100 mg/270 mg of artesunate and amodiaquine, respectively. The recommended total treatment dose per day is 4 mg/kg/day of artesunate and 10 mg/kg/day of amodiaquine given once a day for 3 days.
Do not give Artesunate-Amodiaquine in HIV positive patients who are taking zidovudine, cotrimoxazole and efavirenz. Instead give quinine and clindamycin.
Confirmed treatment failures with ASAQ should be treated with quinine and doxycycline for seven days if not contraindicated. For children under 8 years, give oral quinine and clindamycin. For children weighing less than 5 kg with treatment failure to LA or DP, they should be given ASAQ.
Check doses against the printed guideline and your clinical judgement before treating a patient. Spotted an error? Report it from the contact links below.
Need this without data?
The app holds every guideline on your device, with calculators, bookmarks and notes.