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7.1.6

Treatment regimens for patients previously treated for TB

National TB Management Guidelines, 2018 Edition. Chapter 7, Tuberculosis Management and Monitoring.

Clinical description

Patients eligible for retreatment should be referred for a rapid molecular test r drug susceptibility testing to determine at least rifampicin resistance, and preferably also isoniazid resistance status.

On the basics of the drug susceptibility profile, a standard first-line treatment regimen (2HRZE/4HR) can be repeated if no resistance is documented; and if rifampicin résistance is present, an MDR-TB regimen should be prescribed according to WHO’s recent drug resistant TB treatment guidelines.

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