10.7.3
Chronic Leukemias
Malawi Standard Treatment Guidelines, 6th Edition, 2023. Chapter 10, Oncology.
Clinical Description
- Chronic lymphocytic leukemia (CLL) and chronic myeloid leukemia (CML) are manageable to some extent even in Malawi. Both can be diagnosed with reasonable certainty based on clinical presentation, PBF and bone marrow examination.
Treatment
Treatment options include: Fludarabine, Cyclophosphamide, Rituximab, Chlorambucil for CLL
- For CML: Hydroxyurea can be used for patients before BCR-ABL confirmation
- Imatinib and Nilotinib are available in Malawi through a patient assistance program called Glivec® International Patient Assistance Program (GIPAP).
- GeneXpert provide means of performing molecular testing in Malawi for CML using
BCR-ABL cartilages.
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