10.7.1
Lymphoma
Malawi Standard Treatment Guidelines, 6th Edition, 2023. Chapter 10, Oncology.
Clinical Description
- Refer patient to an Oncology Centre after diagnosis is made.
- If available, refer the patient with current FBC, U +Es and LFT results.
- Basic staging investigations include CXR and abdominal USS
Pharmacological
Chemotherapy
- Aggressive lymphomas have a reasonably good response to a combination of chemotherapeutic agents:
- Cyclophosphamide, Doxorubicin, Vincristine and Prednisolone given once every three weeks (CHOP 21) +/- Rituximab (R-CHOP) for Diffuse Large B-Cell Lymphoma.
- Before starting patients on Doxorubicin, a cardiac ultrasound is required as
Doxorubicin is cardiotoxic.
- Intrathecal chemotherapy may be required depending on patient presentation
- Doxorubicin (Adriamycin), Bleomycin, Vinblastine, Dacarbazine (ABVD) for Hodgkin’s Lymphoma
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